Reproducible porcine model for kidney allotransplantation of low weight miniature pig.

ABSTRACT:

Background

Multiple porcine models have been established to study the mechanisms regarding kidney transplantation. With the development of xenotransplantation, the demand for a low weight miniature pig model has been increasing. A reliable and reproducible surgical technique to establish these models, and to address possible obstacles, has not been sufficiently defined in detail. The goal of the present study was to develop and optimize a low weight miniature pig porcine kidney transplantation model, including a comprehensive surgical description.

Methods

Eight male Bama miniature pigs (12-15 kg) were randomly chosen as kidney donors and, to facilitate investigation of the transplanted kidney, had undergone contralateral nephrectomy. The procured kidneys were perfused with i

SUBMITTER: Zhang M 

PROVIDER: S-EPMC9085933 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature