Assessing bidirectional associations between cognitive impairment and late age-related macular degeneration in the Age-Related Eye Disease Study 2.

ABSTRACT:

Introduction

We aimed to investigate bidirectional associations between cognitive impairment and late age-related macular degeneration (AMD).

Methods

Participants in the Age-Related Eye Disease Study 2 (AREDS2) received annual eye examinations and cognitive function testing (e.g., Modified Telephone Interview for Cognitive Status [TICS-M]). We examined bidirectional associations between cognitive impairment (e.g., a TICS-M score < 30) and late AMD at 5 and 10 years.

Results

Five thousand one hundred eighty-nine eyes (3157 participants; mean age 72.7 years) were analyzed and followed for a median of 10.4 years. Eyes of participants with cognitive impairment at baseline were more likely to progress to late AMD at 5 years (hazard ratio [HR], 1.24; 95% confidence interval

SUBMITTER: Le JT 

PROVIDER: S-EPMC9085971 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature