Integrative metabolomics-genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease.

ABSTRACT: Metabolites, the biochemical products of the cellular process, can be used to measure alterations in biochemical pathways related to the pathogenesis of Alzheimer's disease (AD). However, the relationships between systemic abnormalities in metabolism and the pathogenesis of AD are poorly understood. In this study, we aim to identify AD-specific metabolomic changes and their potential upstream genetic and transcriptional regulators through an integrative systems biology framework for analyzing genetic, transcriptomic, metabolomic, and proteomic data in AD. Metabolite co-expression network analysis of the blood metabolomic data in the Alzheimer's Disease Neuroimaging Initiative (ADNI) shows short-chain acylcarnitines/amino acids and medium/long-chain acylcarnitines are most associated with A

SUBMITTER: Horgusluoglu E 

PROVIDER: S-EPMC9085975 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature