Neural Contributions to the Cochlear Summating Potential: Spiking and Dendritic Components.

ABSTRACT: Using electrocochleography, the summating potential (SP) is a deflection from baseline to tones and an early rise in the response to clicks. Here, we use normal hearing gerbils and gerbils with outer hair cells removed with a combination of furosemide and kanamycin to investigate cellular origins of the SP. Round window electrocochleography to tones and clicks was performed before and after application of tetrodotoxin to prevent action potentials, and then again after kainic acid to prevent generation of an EPSP. With appropriate subtractions of the response curves from the different conditions, the contributions to the SP from outer hair cells, inner hair cell, and neural "spiking" and "dendritic" responses were isolated. Like hair cells, the spiking and dendritic components had opposite

SUBMITTER: Lutz BT 

PROVIDER: S-EPMC9085993 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature