A microarray expression profile and bioinformatic analysis of circular RNA in human esophageal carcinoma.

ABSTRACT:

Background

Recent studies indicate that non-coding circular RNAs (circRNAs) are involved in the development of esophageal carcinoma (EC). This study aimed to identify differential expression of circRNAs in EC, which can provide potential biomarkers and therapeutic targets for EC treatment and improve the understanding of tumorigenesis mechanism.

Methods

First, samples (n=5) of EC tissues and adjacent normal tissue were sent for circRNA microarray detection, Second, further bioinformatic analysis was performed, including circRNA-microRNA (miRNA), co-expression network analysis, Spearman correlation test, and cancer-related circRNA-miRNA axis analysis. Finally, the expression of circRNA that our analysis predicted to be hub genes was verified in samples (n=15) of EC tissues an

SUBMITTER: Cai S 

PROVIDER: S-EPMC9086029 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature