Weighted gene co-expression network analysis reveals prognostic and diagnostic significance of PAQR4 in patients with early and late hepatocellular carcinoma.

ABSTRACT:

Background

This study aimed to reveal novel markers for prognostic and diagnostic prediction of hepatocellular carcinoma (HCC).

Methods

We applied The Cancer Genome Atlas (TCGA) data to screen differentially expressed genes (DEGs). We identified hub modules and genes using weighted gene co-expression network analysis (WGCNA). After verification with the GSE36376 dataset, hub genes were further identified. The expression of progestin and adipoQ receptor 4 (PAQR4) was confirmed in HCC by quantitative reverse transcription polymerase chain reaction (qRT-PCR). The diagnostic and prognosis value of PAQR4 was assessed. The expression of PAQR4 was verified using the GSE76427 dataset.

Results

A total of 803 DEGs were obtained between HCC and

SUBMITTER: Feng T 

PROVIDER: S-EPMC9086035 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature