Safety, Outcomes, and Recommendations for Two-Step Outpatient Nonsteroidal Anti-Inflammatory Drug Challenges.

ABSTRACT:

Background

Nonsteroidal anti-inflammatory drug (NSAID) outpatient challenge protocols are not standardized. They vary in clinical practice and can be time- and resource-intensive to perform.

Objective

To investigate the safety and outcomes of two-step outpatient NSAID challenges to evaluate patients with non-aspirin-exacerbated respiratory disease (AERD)-related NSAID hypersensitivity.

Methods

We conducted a retrospective study of patients with a history of NSAID allergy who underwent outpatient NSAID challenges under allergist supervision. Individuals with AERD were excluded. Patient demographics, NSAID reaction history, and drug challenge details and outcomes were collected.

Results

A total of 249 patients (mean age, 51.6 years; 63.5% female) underwent 262 NS

SUBMITTER: Li L 

PROVIDER: S-EPMC9086081 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature