Impact of African ancestry on the relationship between body mass index and survival in an early-stage breast cancer trial (ECOG-ACRIN E5103).

ABSTRACT:

Background

African ancestry (AA) and obesity are associated with worse survival in early-stage breast cancer. Obesity disproportionately affects women of AA; however, the intersection between ancestry and obesity on breast cancer outcomes remains unclear.

Methods

A total of 2854 patients in the adjuvant trial E5103 were analyzed. Genetic ancestry was determined using principal components from a genome-wide array. The impact of continuous or binary body mass index (BMI) on disease-free survival (DFS) and overall survival (OS) was evaluated by multivariable Cox proportional hazards models in AA patients and European ancestry (EA) patients.

Results

There were 2471 EA patients and 383 AA patients. Higher BMI was significantly associated with worse DFS and OS only in AA pa

SUBMITTER: Ballinger TJ 

PROVIDER: S-EPMC9086123 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature