Reprogramming of red blood cell metabolism in Zika virus-infected donors.

ABSTRACT:

Background

Diseases caused by arthropod-borne viruses remain a burden to global health; in particular, Zika virus (ZIKV) has been reported in 87 countries and territories. In healthy blood donors, ZIKV RNA can be detected in red blood cells (RBCs) months after infection, clearance of detectable nucleic acid in plasma, and seroconversion. However, little information is available on the impact of ZIKV infection to metabolism.

Study design and methods

We applied mass spectrometry-based metabolomics and lipidomics approaches to investigate the impact of ZIKV infection on RBCs over the course of infection. ZIKV-infected blood donors (n = 25) were identified through molecular and serologic methods, which included nucleic acid amplification testing and real-time polymerase chain re

SUBMITTER: Catala A 

PROVIDER: S-EPMC9086146 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature