Exercise Causes Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in Plakophilin-2-Deficient Hearts.

ABSTRACT:

Background

Exercise training, and catecholaminergic stimulation, increase the incidence of arrhythmic events in patients affected with arrhythmogenic right ventricular cardiomyopathy correlated with plakophilin-2 (PKP2) mutations. Separate data show that reduced abundance of PKP2 leads to dysregulation of intracellular Ca²⁺ (Ca²⁺_i) homeostasis. Here, we study the relation between excercise, catecholaminergic stimulation, Ca²⁺_i homeostasis, and arrhythmogenesis in PKP2-deficient murine hearts.

Methods

Experiments were performed in myocytes from a cardiomyocyte-specific, tamoxifen-activated, PKP2 knockout murine line (PKP2cKO). For training, mice underwent 75 minutes of treadmill running once per day, 5 days each week for

SUBMITTER: van Opbergen CJM 

PROVIDER: S-EPMC9086182 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature