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Cobalt(iii)-catalyzed site-selective C-H amidation of pyridones and isoquinolones.

ABSTRACT: In this study, Cp*Co(iii)-catalyzed site-selective amidation of pyridones and isoquinolones using oxazolones as the amidation reagent is reported. This approach features mild conditions, high efficiency and good functional tolerance. Furthermore, gram-scale preparation and preliminary mechanism experiments were carried out. It provides a straightforward approach for the direct modification of pyridone derivatives.

SUBMITTER: Gao F

PROVIDER: S-EPMC9086233 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Cobalt(iii)-catalyzed site-selective C-H amidation of pyridones and isoquinolones.

Gao Feng F Han Xu X Li Chunpu C Liu Lingjun L Cong Zhanqing Z Liu Hong H

RSC advances 20180921 57

In this study, Cp*Co(iii)-catalyzed site-selective amidation of pyridones and isoquinolones using oxazolones as the amidation reagent is reported. This approach features mild conditions, high efficiency and good functional tolerance. Furthermore, gram-scale preparation and preliminary mechanism experiments were carried out. It provides a straightforward approach for the direct modification of pyridone derivatives. ...[more]

PMID: 35547693

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