Dual release kinetics in a single dosage from core-shell hydrogel scaffolds.

ABSTRACT: The development of drug delivery systems with microencapsulated therapeutic agents is a promising approach to the sustained and controlled delivery of various drug molecules. The incorporation of dual release kinetics to such delivery devices further adds to their applicability. Herein, novel core-shell scaffolds composed of sodium deoxycholate and trishydroxymethylaminomethane (NaDC-Tris) have been developed with the aim of delivering two different drugs with variable release rates using the same delivery vehicle. Data obtained from XRD studies, sol-gel transition temperature measurement, rheology and fluorescence studies of the core-shell systems indicate a significant alteration in the core and the shell microstructural properties in a given system as compared to the pure hydrogels of i

SUBMITTER: Khan F 

PROVIDER: S-EPMC9086265 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature