Construction of a Comprehensive Diagnostic Scoring Model for Prostate Cancer Based on a Novel Six-Gene Panel.

ABSTRACT: Accumulating evidence indicates that the N6-methyladenosine (m⁶A) modification plays a critical role in human cancers. Given the current understanding of m⁶A modification, this process is believed to be dynamically regulated by m⁶A regulators. Although the discovery of m⁶A regulators has greatly enhanced our understanding of the mechanism underlying m⁶A modification in cancers, the function and role of m⁶A in the context of prostate cancer (PCa) remain unclear. Here, we aimed to establish a comprehensive diagnostic scoring model that can act as a complement to prostate-specific antigen (PSA) screening. To achieve this, we first drew the landscape of m⁶A regulators and constructed a LASSO-Cox model using three risk

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9086319 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature