Functional and Structural Diversity of Bacterial Contact-Dependent Growth Inhibition Effectors.

ABSTRACT: Bacteria live in complex communities and environments, competing for space and nutrients. Within their niche habitats, bacteria have developed various inter-bacterial mechanisms to compete and communicate. One such mechanism is contact-dependent growth inhibition (CDI). CDI is found in many Gram-negative bacteria, including several pathogens. These CDI⁺ bacteria encode a CdiB/CdiA two-partner secretion system that delivers inhibitory toxins into neighboring cells upon contact. Toxin translocation results in the growth inhibition of closely related strains and provides a competitive advantage to the CDI⁺ bacteria. CdiB, an outer-membrane protein, secretes CdiA onto the surface of the CDI⁺ bacteria. When CdiA interacts with specific target-cell receptors, Cdi

SUBMITTER: Cuthbert BJ 

PROVIDER: S-EPMC9086364 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature