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Recyclable Cu/C₃N₄ composite catalyzed AHA/A³ coupling reactions for the synthesis of propargylamines.

ABSTRACT: The heterogeneous Cu/C₃N₄ catalyst was found to be efficient for the synthesis of propargylamines using a three-component coupling reaction of alkynes, CH₂Cl₂ and amines (AHA) without additional base. Moreover, the catalyst also showed highly catalytic activity in the synthesis of C1-alkynylated tetrahydroisoquinolines (THIQs) via an A³ reaction of alkynes, aldehydes and THIQ. The Cu/C₃N₄-catalyzed multicomponent reactions exhibited good functional group tolerance in most examples. Furthermore, the easily prepared Cu/C₃N₄ catalyst could be recovered and reused conveniently over 5 times without losing catalytic activities.

SUBMITTER: Xu H

PROVIDER: S-EPMC9086382 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Recyclable Cu/C3N4 composite catalyzed AHA/A3 coupling reactions for the synthesis of propargylamines.

Xu Hang H Wang Jun J Wang Peng P Niu Xiyu X Luo Yidan Y Zhu Li L Yao Xiaoquan X

RSC advances 20180924 57

The heterogeneous Cu/C3N4 catalyst was found to be efficient for the synthesis of propargylamines using a three-component coupling reaction of alkynes, CH2Cl2 and amines (AHA) without additional base. Moreover, the catalyst also showed highly catalytic activity in the synthesis of C1-alkynylated tetrahydroisoquinolines (THIQs) via an A3 reaction of alkynes, aldehydes and THIQ. The Cu/C3N4-catalyzed multicomponent ...[more]

PMID: 35547691

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