Dissecting the Effects of Aldosterone and Hypokalemia on the Epithelial Na⁺ Channel and the NaCl Cotransporter.

ABSTRACT: Primary hyperaldosteronism (PA) is characterized by aldosterone excess and hypertension. This may be linked to increased renal Na⁺ reabsorption via the epithelial Na⁺ channel (ENaC) and the NaCl cotransporter (NCC). The majority of PA patients have normal plasma K⁺ levels, but a subset of cases are associated with hypokalemia. High NCC levels observed in long-term studies with aldosterone-infused rodents have been attributed to direct effects of aldosterone. Aldosterone can also increase active phosphorylated NCC (pT58-NCC) acutely. However, direct effects of aldosterone on NCC have been contested by recent studies indicating that it is rather an indirect effect of hypokalemia. We therefore set out to determine isolated long-term aldosterone and K

SUBMITTER: Kristensen M 

PROVIDER: S-EPMC9086401 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature