Agreement of treatment effects from observational studies and randomized controlled trials evaluating hydroxychloroquine, lopinavir-ritonavir, or dexamethasone for covid-19: meta-epidemiological study.

ABSTRACT:

Objective

To systematically identify, match, and compare treatment effects and study demographics from individual or meta-analysed observational studies and randomized controlled trials (RCTs) evaluating the same covid-19 treatments, comparators, and outcomes.

Design

Meta-epidemiological study.

Data sources

National Institutes of Health Covid-19 Treatment Guidelines, a living review and network meta-analysis published in The BMJ, a living systematic review with meta-analysis and trial sequential analysis in PLOS Medicine (The LIVING Project), and the Epistemonikos "Living OVerview of Evidence" (L·OVE) evidence database.

Eligibility criteria for selection of studies

RCTs in The BMJ's living review that directly compared any of the three most

SUBMITTER: Moneer O 

PROVIDER: S-EPMC9086409 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature