Identification of key sex-specific pathways and genes in the subcutaneous adipose tissue from pigs using WGCNA method.

ABSTRACT:

Background

Adipose tissues (ATs), including visceral ATs (VATs) and subcutaneous ATs (SATs), are crucial for maintaining energy and metabolic homeostasis. SATs have been found to be closely related to obesity and obesity-induced metabolic disease. Some studies have shown a significant association between subcutaneous fat metabolism and sexes. However, the molecular mechanisms for this association are still unclear. Here, using the pig as a model, we investigated the systematic association between the subcutaneous fat metabolism and sexes, and identified some key sex-specific pathways and genes in the SATs from pigs.

Results

The results revealed that 134 differentially expressed genes (DEGs) were identified in female and male pigs from the obese group. A total of 17 coexpress

SUBMITTER: Wang H 

PROVIDER: S-EPMC9086418 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature