Effects of the Lipid Metabolites and the Gut Microbiota in ApoE^-/- Mice on Atherosclerosis Co-Depression From the Microbiota-Gut-Brain Axis.

ABSTRACT: Background: The diagnosis, treatment, and prevention of atherosclerosis co-depression are poor, so it is urgent to explore new targets. Based on the "microbiota-gut-brain axis," this study aimed to investigate the changes of lipid metabolites in the prefrontal cortex and hippocampus regions and the characteristics of the gut microbiota in ApoE^-/- mice with atherosclerosis co-depression. Methods: ApoE^-/- mice (hyperlipid feeding combined with binding, HFB group, n = 14, male) fed a high-fat diet for 16 weeks with binding stimulation were used as an animal model for atherosclerosis co-depression. The depression degree of mice was evaluated by body weight, sucrose preference test, open field test, and tail suspension test. Oil-red O staining, HE stai

SUBMITTER: Hu K 

PROVIDER: S-EPMC9086493 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature