Exome sequencing of hepatocellular carcinoma in lemurs identifies potential cancer drivers: A pilot study.

ABSTRACT:

Background and objectives

Hepatocellular carcinoma occurs frequently in prosimians, but the cause of these liver cancers in this group is unknown. Characterizing the genetic changes associated with hepatocellular carcinoma in prosimians may point to possible causes, treatments and methods of prevention, aiding conservation efforts that are particularly crucial to the survival of endangered lemurs. Although genomic studies of cancer in non-human primates have been hampered by a lack of tools, recent studies have demonstrated the efficacy of using human exome capture reagents across primates.

Methodology

In this proof-of-principle study, we applied human exome capture reagents to tumor-normal pairs from five lemurs with hepatocellular carcinoma to characterize the mutational l

SUBMITTER: Gunady EF 

PROVIDER: S-EPMC9086584 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature