Methyl 6-O-cinnamoyl-α-d-glucopyranoside Ameliorates Acute Liver Injury by Inhibiting Oxidative Stress Through the Activation of Nrf2 Signaling Pathway.

ABSTRACT: Excessive stimulation of hepatotoxins and drugs often lead to acute liver injury, while treatment strategies for acute liver injury have been limited. Methyl 6-O-cinnamoyl-α-d-glucopyranoside (MCGP) is a structure modified compound from cinnamic acid, a key chemical found in plants with significant antioxidant, anti-inflammatory, and antidiabetic effects. In this study, we investigated the effects and underlying mechanisms of MCGP on acetaminophen (APAP)- or carbon tetrachloride (CCl₄)-induced acute liver injury. As a result, MCGP inhibited cell death and apoptosis induced by APAP or CCl₄, and suppressed the reactive oxygen species (ROS) generation stimulated by H₂O₂ in liver AML12 cells. In vivo, MCGP alleviated APAP/CCl₄-induc

SUBMITTER: Xu Q 

PROVIDER: S-EPMC9086595 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature