Personalised immunotherapy in sepsis: a scoping review protocol.

ABSTRACT:

Introduction

Sepsis, a life-threatening organ dysfunction syndrome occurring in the context of severe infections, remains a major burden on global health with high morbidity and high mortality rates. Despite recent advances in the understanding of its pathophysiology, the treatment of sepsis remains supportive of nature with few interventions specifically designed for treating this complex syndrome. The focus of sepsis trials has increasingly shifted towards targeting excessive inflammation and immunosuppression using immunomodulatory agents. However, it remains uncertain how to identify patients that could benefit from such treatment, whether treatments can be tailored to an individual's immune profile, or at which stage of the disease the intervention should be initiated. In this

SUBMITTER: Slim MA 

PROVIDER: S-EPMC9086601 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature