Safety and efficacy of intravenous or topical tranexamic acid administration in surgery: a protocol for a systematic review and network meta-analysis.

ABSTRACT:

Introduction

Tranexamic acid (TXA) has become a widely used antifibrinolytic drug for reducing bleeding in surgery. However, adverse events, such as seizures, pulmonary embolism and deep vein thrombosis, limit its application. To date, insufficient attention has been devoted to determining the optimal dosage and administration route of TXA in the field of surgery. Thus, this study uses the network meta-analysis method, relying on its characteristics of combining direct comparison and indirect comparison, to analyse the safety and efficacy of different doses (high, medium, low) of intravenous injection or of topical application of TXA.

Methods and analysis

We will search the PubMed, Cochrane Central Register of Controlled Trials, Embase, Web of Science and China National Know

SUBMITTER: Wang X 

PROVIDER: S-EPMC9086642 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature