Selective internal radiation therapy of hepatic tumors: Morphologic and functional imaging for voxel-based computer-aided dosimetry.

ABSTRACT:

Introduction

Selective Internal Radiation Therapy (SIRT) is used for the treatment of hepatic tumors. The aim of this retrospective study was to compare two dosimetric approaches based on ^99mTc-MAA SPECT/CT and ⁹⁰Y PET/CT, using Simplicit⁹⁰Y™ versus the supplier suggested method of activity calculation.

Material and methods

A total of 19 patients underwent 21 SIRT after baseline angiography and 99mTc-MAA SPECT/CT, followed by 90Y PET/CT. Overlap between 99mTc-MAA and 90Y-microspheres was quantified with different thresholds isocontours. The perfused volume and tumor absorbed dose were estimated using Simplicit90Y™ based on SPECT/CT and PET/CT, then compared with the supplier suggested method. These data were related to overall survival to eva

SUBMITTER: Skanjeti A 

PROVIDER: S-EPMC9086651 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature