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Transition metal/Bronsted acid cooperative catalysis enabled facile synthesis of 8-hydroxyquinolines through one-pot reactions of ortho-aminophenol, aldehydes and alkynes.


ABSTRACT: A convenient and straightforward three-component one-pot strategy has been developed for the synthesis of 8-hydroxyquinoline derivatives. Under the cooperative catalysis of silver(i) triflate and trifluoroacetic acid, ortho-aminophenol reacted with a range of aldehydes and alkynes under mild reactions, affording the corresponding 8-hydroxyquinoline derivatives with good to excellent yields. These transformations exhibited exceptional substrate generality and functional group compatibility.

SUBMITTER: Yu S 

PROVIDER: S-EPMC9086736 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Transition metal/Brønsted acid cooperative catalysis enabled facile synthesis of 8-hydroxyquinolines through one-pot reactions of <i>ortho</i>-aminophenol, aldehydes and alkynes.

Yu Shuyan S   Wu Jingxin J   Lan Hongbing H   Xu Hanwen H   Shi Xiaofei X   Zhu Xuewen X   Yin Zhigang Z  

RSC advances 20180901 59


A convenient and straightforward three-component one-pot strategy has been developed for the synthesis of 8-hydroxyquinoline derivatives. Under the cooperative catalysis of silver(i) triflate and trifluoroacetic acid, <i>ortho</i>-aminophenol reacted with a range of aldehydes and alkynes under mild reactions, affording the corresponding 8-hydroxyquinoline derivatives with good to excellent yields. These transformations exhibited exceptional substrate generality and functional group compatibility  ...[more]

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