Utilizing 3D bioprinted platelet-rich fibrin-based materials to promote the regeneration of oral soft tissue.

ABSTRACT: Oral soft tissue defects remain difficult to treat owing to the limited efficacy of available treatment materials. Although the injectable platelet-rich fibrin (i-PRF) is a safe, autologous source of high levels of growth factors that is often employed to promote the regeneration of oral soft tissue, its effectiveness is restrained by difficulties in intraoperative shaping together with the burst-like release of growth factors. We herein sought to develop a bioactive bioink composed of i-PRF, alginate and gelatin capable of promoting the regeneration of the oral soft tissue. This bioink was successfully applied in 3D bioprinting and exhibited its ability to be shaped to individual patient needs. Importantly, we were also able to significantly prolong the duration of multiple growth factors

SUBMITTER: Yi K 

PROVIDER: S-EPMC9086746 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature