Inflammation, Attention, and Processing Speed in Patients With Breast Cancer Before and After Chemotherapy.

ABSTRACT:

Background

Inflammation may contribute to cognitive difficulties in patients with breast cancer. We tested 2 hypotheses: inflammation is elevated in patients with breast cancer vs noncancer control participants and inflammation in patients is associated with worse attention and processing speed over the course of chemotherapy.

Methods

Serum cytokines (interleukin [IL]-4, 6, 8, 10; tumor necrosis factor [TNF]-α) and soluble receptors [sTNFRI, II]) were measured in 519 females with breast cancer before and after chemotherapy and 338 females without cancer serving as control participants. Attention and processing speed were measured by Rapid Visual Processing (RVP), Backward Counting (BCT), and Trail Making-A (TMT-A) tests. Linear regression models examined patient vs control c

SUBMITTER: Belcher EK 

PROVIDER: S-EPMC9086766 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature