Topologically Disrupted Gray Matter Networks in Drug-Naive Essential Tremor Patients With Poor Sleep Quality.

ABSTRACT:

Background

Sleep disturbances are widespread among patients with essential tremor (ET) and may have adverse effects on patients' quality of life. However, the pathophysiology underlying poor quality of sleep (QoS) in patients with ET remains unclear. Our study aimed to identify gray matter (GM) network alterations in the topological properties of structural MRI related to QoS in patients with ET.

Method

We enrolled 45 ET patients with poor QoS (SleET), 59 ET patients with normal QoS (NorET), and 66 healthy controls (HC), and they all underwent a three-dimensional T1-weighted MRI scan. We used a graph-theoretical approach to investigate the topological organization of GM morphological networks, and individual morphological brain networks were constructed according to the inte

SUBMITTER: Peng J 

PROVIDER: S-EPMC9086904 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature