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Advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted Knoevenagel reaction.

ABSTRACT: A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. The proposed scheme corresponds to the current trends in C-H bond functionalization. The use of aluminum isopropoxide for the Knoevenagel condensation of oxindole with benzophenones is a noticeable point of this work.

SUBMITTER: Novikova DS

PROVIDER: S-EPMC9086994 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Advanced palladium free approach to the synthesis of substituted alkene oxindoles <i>via</i> aluminum-promoted Knoevenagel reaction.

Novikova Daria S DS Grigoreva Tatyana A TA Zolotarev Andrey A AA Garabadzhiu Alexander V AV Tribulovich Vyacheslav G VG

RSC advances 20181010 60

A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. The proposed scheme corresponds to the current trends in C-H bond functionalization. The use of aluminum isopropoxide for the Knoevenagel condensation of oxindole with benzophenones is a noticeable point of this work. ...[more]

PMID: 35548634

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