Synthesis of gamma radiation-induced PEGylated cisplatin for cancer treatment.
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ABSTRACT:
SUBMITTER: Gonzalez Torres M
PROVIDER: S-EPMC9086999 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
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Synthesis of gamma radiation-induced PEGylated cisplatin for cancer treatment.
González Torres Maykel M Cerna Cortez Jorge J Balam Muñoz Soto Rodrigo R Ríos Perez Alfonso A Pfeiffer Heriberto H Pfeiffer Heriberto H Leyva Gómez Gerardo G Zúñiga Ramos Joaquín J Rivera Ana Leonor AL
RSC advances 20181009 60
The use of poly(ethylene glycol) (PEG) for the development of novel PEGylated biomolecules is playing an increasingly meaningful role in cancer treatment. Cisplatin (CDDP), is a useful chemotherapy drug. However, it is unclear whether PEGylated cisplatin (CDDPPEG) has potential as an alternative therapeutic agent. Here we prepared a PEGylated cisplatin by gamma radiation-induced synthesis, for the first time. PEGylated drugs were characterized using Raman and Fourier transform infrared spectrosc ...[more]
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