Hepatocellular Carcinoma in Patients Without Cirrhosis: The Fibrosis Stage Distribution, Characteristics and Survival.

ABSTRACT:

Background

The data on hepatocellular carcinoma (HCC) patients without liver cirrhosis is scarce.

Aims

To study the epidemiology, underlying etiology and fibrosis distribution in noncirrhotic HCC and compare the survival outcomes to cirrhotic HCC.

Methods

We conducted a retrospective study including all adult patients diagnosed with HCC at two US tertiary academic centers from 2000 to 2015. Univariable and multivariable Cox regression analyses were performed to evaluate the variables associated with patient survival.

Results

Two thousand two hundred and thirty-seven HCC patients were included in the final analysis, of which, 13% had no liver cirrhosis. The most common underlying liver disease in non-cirrhotic patients was cryptogenic cause (40%), followed by no

SUBMITTER: Pinyopornpanish K 

PROVIDER: S-EPMC9087017 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature