DNA Polymerase Delta 1 Catalytic Subunit (POLD1) as a Prognostic Factor in Clear Cell Renal Cell Carcinoma Patients.

ABSTRACT:

Background/aim

DNA polymerase delta 1 catalytic subunit (POLD1 or POLD1/p125) plays a crucial role in DNA synthesis and proofreading during the semiconservative genome replication. Mutations of POLD1 are associated with abnormal cell division in various human tumors. However, the significance of altered POLD1 expression in malignant diseases and its usefulness as a prognostic factor is not fully understood. This study aimed to determine POLD1 immunoexpression levels in paired sections of tumor and normal kidney derived from 56 patients with clear cell renal cell carcinoma (ccRCC) and evaluate the significance of POLD1 protein as a potential prognostic factor in ccRCC.

Materials and methods

Tissue samples were collected from 56 patients (27 females and 29 males, mean age 62.6

SUBMITTER: Godlewski J 

PROVIDER: S-EPMC9087055 | biostudies-literature | 2022 May-Jun

REPOSITORIES: biostudies-literature