Identification of Stably Expressed Reference microRNAs in Epithelial Ovarian Cancer.

ABSTRACT:

Background/aim

MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression and have been associated with the development of various cancers, including epithelial ovarian cancer (EOC). Accurate quantification of miRNA levels is important for determining their role in tumorigenesis and as biomarkers. Currently, U6 is widely used as a normalization control when investigating miRNAs in EOC; however, its variable expression across cancers has been reported. As only a few studies have been published to date on the identification of endogenous miRNA controls in EOC, our aim was to identify stable miRNAs based on global microarray profiling of 197 EOC patients and verify their stability in external datasets.

Materials and methods

We collected miRNA-microarray

SUBMITTER: Lopacinska-Joergensen J 

PROVIDER: S-EPMC9087112 | biostudies-literature | 2022 May-Jun

REPOSITORIES: biostudies-literature