Association of miRNA-145 Single Nucleotide Polymorphisms in Abdominal Aortic Aneurysms.

ABSTRACT:

Background/aim

MicroRNAs (miRNAs) are non-coding RNA molecules that exert post-transcriptional gene expression regulation in response to cellular or environmental changes. Genetic variation affects their synthesis and cellular actions, and single nucleotide polymorphisms (SNPs) are one example of genetic variants studied in relation to various diseases. Literature indicates that the differentially expressed miRNA-145 in patients' serum is an essential biomarker for abdominal aortic aneurysm (AAA). However, the correlation between specific miR-145 genetic polymorphisms with AAA susceptibility is inadequately studied.

Materials and methods

Eighty-seven AAA patients and 122 healthy controls were recruited. Peripheral blood samples were genotyped for miRNA-145 SNPs; rs55945735,

SUBMITTER: Hasemaki N 

PROVIDER: S-EPMC9087113 | biostudies-literature | 2022 May-Jun

REPOSITORIES: biostudies-literature