Systematic review of the safety, immunogenicity, and effectiveness of COVID-19 vaccines in pregnant and lactating individuals and their infants.

ABSTRACT:

Background

There is significant risk of complications and vulnerability to severe COVID-19 disease in pregnancy, yet hesitancy exists around COVID-19 vaccination during pregnancy and lactation.

Objective

To summarize the safety, immunogenicity, and effectiveness of COVID-19 vaccines in pregnancy and lactation.

Search strategy

A systematic search of MEDLINE, Embase, PubMed, medRxiv, and bioRxiv.

Selection criteria

Identified original studies published on pregnant and/or lactating individuals who received one or more doses of a COVID-19 vaccine.

Data collection and analysis

A descriptive summary organized by safety, immunogenicity, and effectiveness outcomes of COVID-19 vaccination in pregnancy and lactation.

Main results

In total, 23 studies were i

SUBMITTER: Fu W 

PROVIDER: S-EPMC9087489 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature