Dataset Information

Consequences and implications of the coronavirus disease (COVID-19) on pregnancy and newborns: A comprehensive systematic review and meta-analysis.

ABSTRACT:

Background

Pregnant patients are potentially vulnerable to COVID-19.

Objectives

To clarify the clinical features of COVID-19 and analyze maternal/fetal morbidity and mortality and the obstetric and neonatal outcomes of pregnant patients.

Search strategy

Embase, PubMed, Web of Science, CINAHAL, LILACS, Google Scholar, and Scopus.

Selection criteria

Articles published from December 2019 to February 2021.

Data collection and analysis

The reviewers extracted relevant data from the full-text. Data synthesis was performed using the R-4.1.0 Project for Statistical Computing for Windows. The meta-analysis of the included studies was carried out using the random-effects model (DerSimonian and Laird). Heterogeneity was measured using I² analysis.

Results

A total of 70 studies included 10 047 pregnant women with COVID-19, of whom 71.6% were in their third trimester. The most common symptoms were fever, cough, chest pain, dyspnea, and fatigue. Most newborns were delivered preterm (24%, 95% confidence interval [CI] 0.17-0.34, I² = 93%) and via cesarean delivery (42%, 95% CI 0.38-0.47, I² = 92%). There were 108 maternal mortalities (2%, 95% CI 0.01-0.03, I² = 54%) and 50 abortions (5%, 95% CI 0.03-0.09, I² = 73%). The neonatal outcomes included fetal distress (11%, 95% CI 0.06-0.19, I² = 91%), birth weight (15%, 95% CI 0.10-0.21, I² = 76%), APGAR <7 (19%, 95% CI 0.12-0.28, I² = 43%), admission to the neonatal intensive care unit (28%, 95% CI 0.17-0.43, I² = 90%), and fetal mortality (2%, 95% CI 0.01-0.03, I² = 46%).

Conclusion

There was no evidence of severe acute respiratory syndrome coronavirus-2 in the placenta, breast milk, umbilical cord, and amniotic fluid of pregnant patients. PROSPERO registration number: CRD42020181519.

SUBMITTER: de Medeiros KS

PROVIDER: S-EPMC9087607 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Consequences and implications of the coronavirus disease (COVID-19) on pregnancy and newborns: A comprehensive systematic review and meta-analysis.

de Medeiros Kleyton S KS Sarmento Ayane C A ACA Costa Ana P F APF Macêdo Luíza T de A LTA da Silva Luís A S LAS de Freitas Cijara L CL Simões Ana C Z ACZ Gonçalves Ana K AK

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20211119 3

<h4>Background</h4>Pregnant patients are potentially vulnerable to COVID-19.<h4>Objectives</h4>To clarify the clinical features of COVID-19 and analyze maternal/fetal morbidity and mortality and the obstetric and neonatal outcomes of pregnant patients.<h4>Search strategy</h4>Embase, PubMed, Web of Science, CINAHAL, LILACS, Google Scholar, and Scopus.<h4>Selection criteria</h4>Articles published from December 2019 to February 2021.<h4>Data collection and analysis</h4>The reviewers extracted relev ...[more]

PMID: 34762735

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Project description:BackgroundLiver function derangements have been reported in coronavirus disease (COVID-19), but reported rates are variable.MethodsWe searched PubMed and Embase with terms COVID and SARS-COV-2 from December 1, 2019 till April 5, 2020. We estimated overall prevalence, stratified prevalence based on severity, estimated risk ratio (RR), and estimated standardized mean difference (SMD) of liver function parameters in severe as compared to non-severe COVID. Random effect method utilizing inverse variance approach was used for pooling the data.ResultsIn all, 128 studies were included. The most frequent abnormalities were hypoalbuminemia [61.27% (48.24-72.87)], elevations of gamma-glutamyl transferase (GGT) [27.94% (18.22-40.27)], alanine aminotransferase (ALT) [23.28% (19.92-27.01)], and aspartate aminotransferase (AST) [23.41% (18.84-28.70)]. Furthermore, the relative risk of these abnormalities was higher in the patients with severe COVID-19 when compared to non-severe disease [Hypoalbuminemia-2.65 (1.38-5.07); GGT-2.31 (1.6-3.33); ALT-1.76 (1.44-2.15); AST-2.30 (1.82-2.90)]. The SMD of hypoalbuminemia, GGT, ALT, and AST elevation in severe as compared to non-severe were - 1.05 (- 1.27 to - 0.83), 0.76 (0.40-1.12), 0.42 (0.27-0.56), and 0.69 (0.52-0.86), respectively. The pooled prevalence and RR of chronic liver disease as a comorbidity was 2.64% (1.73-4) and 1.69 (1.05-2.73) respectively.ConclusionThe most frequent abnormality in liver functions was hypoalbuminemia followed by derangements in gamma-glutamyl transferase and aminotransferases, and these abnormalities were more frequent in severe disease. The systematic review was, however, limited by heterogeneity in definitions of severity and liver function derangements. Graphical depiction of the summary of meta-analytic findings a) pooled prevalence of abnormalities b) Risk ratio of abnormality in severe versus non-severe COVID-19 c) standardized mean difference (SMD) between severe and non-severe group and d) pooled prevalence for parameters based on severity stratification for bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), albumin, globulin and acute hepatic injury (AHI) . Also estimates for overall/total liver disease (TLD) and chronic liver disease (CLD) amongst COVID-19 patients are depicted in a, b, d. For d) In addition to severity stratification, Overall (all studies for a particular estimate) and combined (only those studies which reported severity) estimates are provided.

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Dataset Information

Consequences and implications of the coronavirus disease (COVID-19) on pregnancy and newborns: A comprehensive systematic review and meta-analysis.

Background

Objectives

Search strategy

Selection criteria

Data collection and analysis

Results

Conclusion

Publications

Consequences and implications of the coronavirus disease (COVID-19) on pregnancy and newborns: A comprehensive systematic review and meta-analysis.

Similar Datasets

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