Dataset Information

Maternal death related to COVID-19: A systematic review and meta-analysis focused on maternal co-morbidities and clinical characteristics.

ABSTRACT:

Background

Besides reducing the quality of obstetric care, the direct impact of COVID-19 on pregnancy and postpartum is uncertain.

Objective

To evaluate the characteristics of pregnant women who died due to COVID-19.

Search strategy

Cochrane Library, Embase, MEDLINE, Scopus, and Google Scholar were searched from inception to February 2021.

Selection criteria

Studies that compared deceased and survived pregnant women with COVID-19.

Data collection and analysis

Relevant data were extracted and tabulated. The primary outcome was maternal co-morbidity.

Main results

Thirteen studies with 154 deceased patients were included. Obesity doubled the risk of death (relative risk [RR] 2.48, 95% confidence interval [CI] 1.41-4.36, I² = 0%). No differences were found for gestational diabetes (RR 5.71; 95% CI 0.77-42.44, I² = 94%) or asthma (RR 2.05, 95% CI 0.81-5.15, I² = 0%). Overall, at least one severe co-morbidity showed a twofold increased risk of death (RR 2.26, 95% CI 1.77-2.89, I² = 76%). Admission to intensive care was related to a fivefold increased risk of death (RR 5.09, 95% CI 2.00-12.98, I² = 56%), with no difference in need for respiratory support (RR 0.53, 95% CI 0.23-1.48, I² = 95%) or mechanical ventilation (RR 4.34, 95% CI 0.96-19.60, I² = 58%).

Conclusion

COVID-19 with at least one co-morbidity increases risk of intensive care and mortality.

SUBMITTER: La Verde M

PROVIDER: S-EPMC9087672 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Maternal death related to COVID-19: A systematic review and meta-analysis focused on maternal co-morbidities and clinical characteristics.

La Verde Marco M Riemma Gaetano G Torella Marco M Cianci Stefano S Savoia Fabiana F Licciardi Federico F Scida Serena S Morlando Maddalena M Colacurci Nicola N De Franciscis Pasquale P

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20210518 2

<h4>Background</h4>Besides reducing the quality of obstetric care, the direct impact of COVID-19 on pregnancy and postpartum is uncertain.<h4>Objective</h4>To evaluate the characteristics of pregnant women who died due to COVID-19.<h4>Search strategy</h4>Cochrane Library, Embase, MEDLINE, Scopus, and Google Scholar were searched from inception to February 2021.<h4>Selection criteria</h4>Studies that compared deceased and survived pregnant women with COVID-19.<h4>Data collection and analysis</h4> ...[more]

PMID: 33930185

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Project description:BackgroundHigh prevalence, severity, and formidable morbidity have marked the recent emergence of the novel coronavirus disease (COVID-19) pandemic. The significant association with the pre-existing co-morbid conditions has increased the disease burden of this global health emergency, pushing the patients, healthcare workers and facilities to the verge of complete disruption.MethodsMeta-analysis of pooled data was undertaken to assess the cumulative risk assessment of multiple co-morbid conditions associated with severe COVID-19. PubMed, Scopus, and Google Scholar were searched from January 1st to June 27th 2020 to generate a well-ordered, analytical, and critical review. The exercise began with keying in requisite keywords, followed by inclusion and exclusion criteria, data extraction, and quality evaluation. The final statistical meta-analysis of the risk factors of critical/severe and non-critical COVID-19 infection was carried out on Microsoft Excel (Ver. 2013), MedCalc (Ver.19.3), and RevMan software (Ver.5.3).ResultsWe investigated 19 eligible studies, comprising 12037 COVID-19 disease patients, representing the People's Republic of China (PRC), USA, and Europe. 18.2% (n = 2200) of total patients had critical/severe COVID-19 disease. The pooled analysis showed a significant association of COVID-19 disease severity risk with cardiovascular disease (RR: 3.11, p < 0.001), followed by diabetes (RR: 2.06, p < 0.001), hypertension (RR: 1.54, p < 0.001), and smoking (RR: 1.52, p < 006).ConclusionThe review involved a sample size of 12037 COVID-19 patients across a wide geographical distribution. The reviewed reports have focussed on the association of individual risk assessment of co-morbid conditions with the heightened risk of COVID-19 disease. The present meta-analysis of cumulative risk assessment of co-morbidity from cardiovascular disease, diabetes, hypertension, and smoking signals a novel interpretation of inherent risk factors exacerbating COVID-19 disease severity. Consequently, there exists a definite window of opportunity for increasing survival of COVID-19 patients (with high risk and co-morbid conditions) by timely identification and implementation of appropriately suitable treatment modalities.

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Dataset Information

Maternal death related to COVID-19: A systematic review and meta-analysis focused on maternal co-morbidities and clinical characteristics.

Background

Objective

Search strategy

Selection criteria

Data collection and analysis

Main results

Conclusion

Publications

Maternal death related to COVID-19: A systematic review and meta-analysis focused on maternal co-morbidities and clinical characteristics.

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