Tanhuo Formula Inhibits Astrocyte Activation and Apoptosis in Acute Ischemic Stroke.

ABSTRACT: Tanhuo formula (THF), a traditional Chinese medicinal formula, has been demonstrated to be effective in the clinical treatment of acute ischemic stroke (AIS). However, its active ingredients, potential targets, and molecular mechanisms remain unknown. Based on the validation of active ingredient concentrations, our study attempted to elucidate the possible mechanisms of THF based on network pharmacological analysis and experimental validation. Components of THF were screened using network pharmacological analysis, and a compound-target network and protein-protein interaction (PPI) network were constructed. In total, 42 bioactive compounds and 159 THF targets related to AIS were identified. The PPI network identified AKT1, TNF, IL6, IL1B, and CASP3 as key targets. Kyoto Encyclopedia of Gene

SUBMITTER: Nie Y 

PROVIDER: S-EPMC9087855 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature