Effects of transcranial alternating current stimulation on spiking activity in computational models of single neocortical neurons.

ABSTRACT: Neural oscillations are a key mechanism for information transfer in brain circuits. Rhythmic fluctuations of local field potentials control spike timing through cyclic membrane de- and hyperpolarization. Transcranial alternating current stimulation (tACS) is a non-invasive neuromodulation method which can directly interact with brain oscillatory activity by imposing an oscillating electric field on neurons. Despite its increasing use, the basic mechanisms of tACS are still not fully understood. Here, we investigate in a computational study the effects of tACS on morphologically realistic neurons with ongoing spiking activity. We characterize the membrane polarization as a function of electric field strength and subsequent effects on spiking activity in a set of 25 neurons from different ne

SUBMITTER: Tran H 

PROVIDER: S-EPMC9087863 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature