High-throughput lipidomics reveal mirabilite regulating lipid metabolism as anticancer therapeutics.

ABSTRACT: Altered lipid metabolism is an emerging hallmark of cancers. Mirabilite has a therapeutic effect on colorectal cancer (CRC); however, its metabolic mechanism remains unclear. This study aims to explore the potential therapeutic targets of mirabilite protection against colorectal cancer in APC^min/+ mice model. Oral administration of mirabilite was started from the ninth month, while the same dosage of distilled water was given to both the control group and the model group. Based on lipidomics, we collected serum samples of all mice at the 20^th week and used a non-targeted method to identify the lipid biomarkers of CRC. Compared with C57BL/6J mice, the metabolic profile of CRC model mice was significantly disturbed, and we identified that 25 lipid-related biomarkers, in

SUBMITTER: Zhang HL 

PROVIDER: S-EPMC9087915 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature