Development and validation of a radiomics-based nomogram for the preoperative prediction of microsatellite instability in colorectal cancer.

ABSTRACT:

Background

Preoperative prediction of microsatellite instability (MSI) status in colorectal cancer (CRC) patients is of great significance for clinicians to perform further treatment strategies and prognostic evaluation. Our aims were to develop and validate a non-invasive, cost-effective reproducible and individualized clinic-radiomics nomogram method for preoperative MSI status prediction based on contrast-enhanced CT (CECT)images.

Methods

A total of 76 MSI CRC patients and 200 microsatellite stability (MSS) CRC patients with pathologically confirmed (194 in the training set and 82 in the validation set) were identified and enrolled in our retrospective study. We included six significant clinical risk factors and four qualitative imaging data extracted from CECT images to

SUBMITTER: Ying M 

PROVIDER: S-EPMC9087961 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature