Machine learning and statistics shape a novel path in archaeal promoter annotation.

ABSTRACT:

Background

Archaea are a vast and unexplored domain. Bioinformatic techniques might enlighten the path to a higher quality genome annotation in varied organisms. Promoter sequences of archaea have the action of a plethora of proteins upon it. The conservation found in a structural level of the binding site of proteins such as TBP, TFB, and TFE aids RNAP-DNA stabilization and makes the archaeal promoter prone to be explored by statistical and machine learning techniques.

Results and discussions

In this study, experimentally verified promoter sequences of the organisms Haloferax volcanii, Sulfolobus solfataricus, and Thermococcus kodakarensis were converted into DNA duplex stability attributes (i.e. numerical variables) and were classified through Artificial Neural Networks an

SUBMITTER: Martinez GS 

PROVIDER: S-EPMC9087966 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature