Recurrence of IgA nephropathy after kidney transplantation: experience from the Swiss transplant cohort study.

ABSTRACT:

Background

Recurrence of IgA nephropathy (IgAN) after kidney transplantation occurs in about 30% of patients. The relevance of recurrence for the long-term graft survival is expected to increase, since graft survival continues to improve.

Methods

In a nested study within the Swiss Transplant Cohort Study the incidence of IgAN recurrence, predictive factors, graft function and graft and patient survival were evaluated. Serum concentration of total IgA, total IgG, Gd-IgA1 and IgA-IgG immune complex were measured using ELISA-based immunologic assays.

Results

Between May 2008 and December 2016, 28 women and 133 men received their kidney allograft for end-stage kidney disease due to IgAN in Switzerland. Over a median follow-up time of 7 years after transplantation, 43 out

SUBMITTER: Jager C 

PROVIDER: S-EPMC9088042 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature