Theranostic nanocomposite from upconversion luminescent nanoparticles and black phosphorus nanosheets.

ABSTRACT: An anti-cancer campaign might not be easily achieved through a single therapeutic modality. Collaboration of multimodal therapies and diagnosis could be vital to win the battle against cancer. In this context, we synthesized a multifunctional theranostic nanocomposite (UCNP-BPNS) from upconversion nanoparticles (UCNP) and black phosphorus nanosheets (BPNS) for synergistic photothermal/photodynamic therapies in vitro and dual modal imaging. Core-shell UCNP (NaYF₄:Yb,Er@NaGdF₄) and BPNS were synthesized using solvo-thermal and liquid exfoliation methods, respectively, and then covalently conjugated after UCNP was modified with polyacrylic acid and BPNS with methoxypolyethylene glycol amine. The experimental results validate that the nanocomposite exhibited a good

SUBMITTER: Dibaba ST 

PROVIDER: S-EPMC9088079 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature