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Reconstruction of the origin of the first major SARS-CoV-2 outbreak in Germany.

ABSTRACT: The first major COVID-19 outbreak in Germany occurred in Heinsberg in February 2020 with 388 officially reported cases. Unexpectedly, the first outbreak happened in a small town with little to no travelers. We used phylogenetic analyses to investigate the origin and spread of the virus in this outbreak. We sequenced 90 (23%) SARS-CoV-2 genomes from the 388 reported cases including the samples from the first documented cases. Phylogenetic analyses of these sequences revealed mainly two circulating strains with 74 samples assigned to lineage B.3 and 6 samples assigned to lineage B.1. Lineage B.3 was introduced first and probably caused the initial spread. Using phylogenetic analysis tools, we were able to identify closely related strains in France and hypothesized the possible introduction from France.

SUBMITTER: Korencak M 

PROVIDER: S-EPMC9088089 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Reconstruction of the origin of the first major SARS-CoV-2 outbreak in Germany.

Korencak Marek M   Sivalingam Sugirthan S   Sahu Anshupa A   Dressen Dietmar D   Schmidt Axel A   Brand Fabian F   Krawitz Peter P   Hart Libor L   Maria Eis-Hübinger Anna A   Buness Andreas A   Streeck Hendrik H  

Computational and structural biotechnology journal 20220510

The first major COVID-19 outbreak in Germany occurred in Heinsberg in February 2020 with 388 officially reported cases. Unexpectedly, the first outbreak happened in a small town with little to no travelers. We used phylogenetic analyses to investigate the origin and spread of the virus in this outbreak. We sequenced 90 (23%) SARS-CoV-2 genomes from the 388 reported cases including the samples from the first documented cases. Phylogenetic analyses of these sequences revealed mainly two circulatin  ...[more]

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