Serum β-catenin changes vary among different stages of osteonecrosis of the femoral head: an exploratory biomarker study.

ABSTRACT:

Background

Wnt/β-catenin signaling pathway is closely related to the pathogenesis Osteonecrosis of the femoral head (ONFH). β-catenin, as a major component of Wnt signaling pathway, plays a vital role in the proliferation of osteoblasts. But the effect of altering β-catenin level on the early diagnosis and staging of ONFH has not been studied. Our purpose is to investigate the role of β-catenin level in the progress of ONFH.

Method

One hundred and one patients with three stages of ONFH and fifty healthy controls were recruited between May 2016 and November 2016. We divided the patients into 32 cases of stage II, 41 cases of stage III and 28 cases of stage IV according to the Association Research Circulation Osseous (ARCO) classification. We evaluated the clinical bone histom

SUBMITTER: Huang J 

PROVIDER: S-EPMC9088107 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature