Oligoproline-derived nanocarrier for dual stimuli-responsive gene delivery.

ABSTRACT: Gene therapy is a promising method for the treatment of vascular disease; however, successful strategies depend on the development of safe and effective delivery technologies with specific targeting to a diseased point of vasculature. Reactive oxygen species (ROS) are overproduced by vascular smooth muscle cells (VSMCs) at critical stages of atherosclerosis progression. Therefore, ROS were exploited as a stimulus for vascular targeted gene delivery in this study. A combination of bio-conjugation methods and controlled reverse addition-fragmentation chain-trasfer (RAFT) polymerization was utilized to synthesize a new ROS-cleavable, pH-responsive mPEG₁₁₃-b-CP₅K-b-PDMAEMA₄₂-b-P(DMAEMA₂₂-co-BMA₄₀-co-PAA₂₄) (PPDDBP) polymer as a

SUBMITTER: Gupta MK 

PROVIDER: S-EPMC9088177 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature