Interactions between β-cyclodextrin and tea catechins, and potential anti-osteoclastogenesis activity of the (-)-epigallocatechin-3-gallate-β-cyclodextrin complex.

ABSTRACT: Galloylated catechins, the most important secondary metabolites in green tea including (-)-epigallocatechin-3-gallate (EGCG) and (-)-epicatechin-3-gallate, constitute nearly 75% of all tea catechins and have stronger health effects than non-galloylated catechins such as (-)-epigallocatechin and (-)-epicatechin. EGCG is the most abundant, active, and thoroughly investigated compound in green tea, and its bioactivity might be improved by complexing with β-cyclodextrin (β-CD). We investigated interactions between four catechins and β-CD in a PBS buffer solution of pH 6.5 at 25 °C using biolayer interferometry and isothermal titration calorimetry, and to determine whether β-CD could enhance the anti-osteoclastogenesis effect of EGCG. β-CD could directly bind galloylated catechins at a stoichio

SUBMITTER: Xu H 

PROVIDER: S-EPMC9088451 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature