Characterization of memory T cell subsets and common γ-chain cytokines in convalescent COVID-19 individuals.

ABSTRACT: T cells are thought to be an important correlates of protection against SARS-CoV2 infection. However, the composition of T cell subsets in convalescent individuals of SARS-CoV2 infection has not been well studied. The authors determined the lymphocyte absolute counts, the frequency of memory T cell subsets, and the plasma levels of common γ-chain in 7 groups of COVID-19 individuals, based on days since RT-PCR confirmation of SARS-CoV-2 infection. The data show that both absolute counts and frequencies of lymphocytes as well as, the frequencies of CD4⁺ central and effector memory cells increased, and the frequencies of CD4⁺ naïve T cells, transitional memory, stem cell memory T cells, and regulatory cells decreased from Days 15-30 to Days 61-90 and plateaued thereafter

SUBMITTER: Rajamanickam A 

PROVIDER: S-EPMC9088480 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature