Circulating B10 regulatory cells are decreased in severe and critical COVID-19.

ABSTRACT: The contribution of B cells in COVID-19 pathogenesis, beyond the production of specific antibodies against SARS-CoV-2, is still not well understood. Since one of their most relevant functional roles includes their immune-suppressive mechanisms, we decided to evaluate one of the most recognized human B regulatory subpopulations: the IL-10⁺ B10 cells, during COVID-19 onset. After stimulation of PBMCs for IL-10 induction, we employed multiparametric flow cytometry to determine B10 frequencies in severe and critical COVID-19 patients and then correlated those with clinical and laboratory parameters. Compared with healthy individuals, we detected a significant reduction in the B10 subset in both patient groups, which correlates with some inflammatory parameters that define the diseas

SUBMITTER: Cervantes-Diaz R 

PROVIDER: S-EPMC9088486 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature